What is the primary function of the chemokine receptor CXCR4 in hematopoiesis?

A To regulate the proliferation of hematopoietic stem cells
B To mediate the homing of hematopoietic stem cells to the bone marrow ✓
C To inhibit the differentiation of hematopoietic stem cells
D To induce the apoptosis of hematopoietic stem cells

Explanation

CXCR4 plays a crucial role in the homing of hematopoietic stem cells to the bone marrow by interacting with its ligand, SDF-1.

Source

Blood journal
Hematology Hematology: Hematopoiesis Hematology: Hematopoiesis Medium MEDICAL Confidence: high