What is the primary function of hepcidin in the regulation of iron metabolism in anemia?

A To increase iron absorption from the gut
B To decrease iron release from macrophages ✓
C To regulate iron recycling from senescent erythrocytes
D To inhibit erythropoiesis

Explanation

Hepcidin plays a crucial role in regulating iron metabolism by binding to ferroportin, leading to its internalization and degradation, thereby decreasing iron release from macrophages and other cells.

Source

Guyton and Hall Textbook of Medical Physiology
Hematology Hematology: Anemia Hematology: Anemia Medium MEDICAL Confidence: high