What is the primary effect of an increase in 2,3-Bisphosphoglycerate (2,3-BPG) on hemoglobin's oxygen binding properties?

A Increases oxygen affinity
B Decreases oxygen affinity ✓
C Has no effect on oxygen affinity
D Increases the production of hemoglobin

Explanation

2,3-BPG is an allosteric effector that binds to hemoglobin and decreases its oxygen affinity, facilitating the release of oxygen to tissues.

Source

Guyton and Hall Textbook of Medical Physiology
Hematology Hematology: Hemoglobin and Oxygen Transport Hematology: Hemoglobin and Oxygen Transport Medium MEDICAL Confidence: high