What is the primary cause of lactic acidosis in diabetic patients?

A Impaired glucose uptake in muscles
B Increased glucose production in the liver ✓
C Defective mitochondrial function
D Excessive fatty acid oxidation

Explanation

Lactic acidosis in diabetic patients is primarily caused by increased glucose production in the liver, which leads to an accumulation of lactate.

Source

Harrison's Principles of Internal Medicine
Metabolic and Nutritional Disorders Diabetes Mellitus Diabetic Complications Medium MEDICAL Confidence: high