What is the primary cause of lactic acidosis in diabetic patients with uncontrolled hyperglycemia?

A Increased glucose uptake in muscles
B Impaired fatty acid oxidation
C Enhanced glycolysis ✓
D Reduced insulin secretion

Explanation

Uncontrolled hyperglycemia leads to increased glucose uptake in cells, which in turn increases glycolysis, resulting in the production of lactic acid and causing lactic acidosis.

Source

Harrison's Principles of Internal Medicine
Metabolic and Nutritional Disorders Diabetes Mellitus Diabetic Ketoacidosis and Lactic Acidosis Medium MEDICAL Confidence: high