What is the name of the metabolic disorder characterized by the accumulation of lactate in the blood due to a deficiency in the enzyme pyruvate dehydrogenase?

A Lactic acidosis ✓
B Ketoacidosis
C Maple syrup urine disease
D Pyruvate kinase deficiency

Explanation

Lactic acidosis is a metabolic disorder characterized by the accumulation of lactate in the blood due to a deficiency in the enzyme pyruvate dehydrogenase, which is necessary for the conversion of pyruvate to acetyl-CoA.

Source

Harper's Illustrated Biochemistry
Metabolic and Nutritional Disorders Metabolic Disorders Disorders of Carbohydrate Metabolism Hard MEDICAL Confidence: high