What is the name of the enzyme that is deficient in individuals with Gaucher's disease, a lysosomal storage disorder characterized by the accumulation of glucocerebroside in cells?
Explanation
Gaucher's disease is caused by a deficiency of the enzyme glucocerebrosidase, which is responsible for breaking down glucocerebroside into glucose and ceramide. The accumulation of glucocerebroside leads to the characteristic symptoms of the disease.
Mnemonic
'Gaucher' sounds like 'go cher', go find the deficient enzyme
Source
Scriver's The Metabolic and Molecular Bases of Inherited Disease