What is the name of the enzyme deficiency that leads to the accumulation of phenylalanine in the body, causing phenylketonuria?

A Phenylalanine hydroxylase ✓
B Tyrosinase
C Dihydropteridine reductase
D Homogentisate 1,2-dioxygenase

Explanation

Phenylalanine hydroxylase is the enzyme responsible for converting phenylalanine to tyrosine. A deficiency in this enzyme leads to the accumulation of phenylalanine, causing phenylketonuria.

Source

OMIM Database
Enzymes in Disease Biochemistry Amino Acid Metabolism Disorders Medium MEDICAL Confidence: high