What is the name of the disorder characterized by the production of an abnormal form of hemoglobin, which causes red blood cells to be misshapen and break down prematurely?

A Sickle cell anemia ✓
B Thalassemia
C Glucose-6-phosphate dehydrogenase deficiency
D Hereditary spherocytosis

Explanation

Sickle cell anemia is a genetic disorder caused by a mutation in the HBB gene, leading to the production of abnormal hemoglobin S, which causes red blood cells to become misshapen and break down prematurely.

Source

Robbins and Cotran Pathologic Basis of Disease
Hematology Hematology: Hemoglobin and Oxygen Transport Hematology: Hemoglobin and Oxygen Transport Medium MEDICAL Confidence: high