What is the mechanism by which hepcidin regulates iron metabolism in the context of anemia?

A By inhibiting the expression of ferroportin ✓
B By stimulating the production of erythropoietin
C By increasing the absorption of iron from the gut
D By reducing the recycling of iron from macrophages

Explanation

Hepcidin plays a central role in iron metabolism by regulating the expression of ferroportin, the only known iron exporter, thus controlling iron efflux from cells and its subsequent availability for erythropoiesis.

Source

Journal of Clinical Investigation
Hematology Hematology: Anemia Hematology: Anemia Hard MEDICAL Confidence: high