What is the function of the stromal cell-derived factor 1 (SDF-1) in the hematopoietic microenvironment?

A It inhibits the adhesion of hematopoietic stem cells to the bone marrow niche
B It promotes the homing and retention of hematopoietic stem cells in the bone marrow ✓
C It regulates the differentiation of hematopoietic progenitor cells into mature blood cells
D It induces the mobilization of hematopoietic stem cells from the bone marrow to the peripheral blood

Explanation

SDF-1, also known as CXCL12, is a chemokine that plays a crucial role in promoting the homing and retention of hematopoietic stem cells in the bone marrow, ensuring their ability to interact with the hematopoietic microenvironment.

Source

Lopez-Otin et al. Hallmarks of Cancer
Hematology Hematology: Hematopoiesis Hematology: Hematopoiesis Hard MEDICAL Confidence: high