What is the effect of an increase in pH on the oxygen-binding curve of hemoglobin?

A It shifts the curve to the right, decreasing oxygen affinity
B It shifts the curve to the left, increasing oxygen affinity ✓
C It has no effect on the oxygen-binding curve
D It decreases the cooperativity of oxygen binding

Explanation

An increase in pH (alkalosis) shifts the oxygen-binding curve of hemoglobin to the left, increasing its affinity for oxygen.

Mnemonic

pH increase = Left shift, Increased affinity

Source

Berne and Levy Physiology
Hematology Hematology: Hemoglobin and Oxygen Transport Hematology: Hemoglobin and Oxygen Transport Hard MEDICAL Confidence: high