What is the clinical significance of the Lewis blood group system in relation to transfusion medicine?

A It can cause a hemolytic transfusion reaction
B It is associated with an increased risk of bleeding disorders
C It can affect the outcome of pregnancy in certain individuals
D It is not clinically significant in transfusion medicine
The Lewis blood group system can cause a hemolytic transfusion reaction if incompatible blood is transfused, as the recipient's immune system may react with the donor's red blood cells.
American Association of Blood Banks
Hematology Hematology: Blood Grouping and Crossmatching Hematology: Blood Grouping and Crossmatching Medium MEDICAL Confidence: high