How does the phenomenon of 'electrostatic repulsion' contribute to the ABO blood group system's role in transfusion reactions?

A It enhances the binding of antibodies to red blood cells
B It reduces the risk of hemolysis due to ABO incompatibility
C It has no significant impact on ABO blood group system's role in transfusion reactions
D It helps to prevent the agglutination of red blood cells by creating a repulsive force between them ✓

Explanation

The electrostatic repulsion between red blood cells, due to their negatively charged surfaces, helps to prevent agglutination. However, when antibodies bind to the ABO antigens, they can overcome this repulsion, leading to agglutination and potential hemolysis.

Source

Textbooks on immunohematology and transfusion medicine
Hematology Hematology: Blood Grouping and Crossmatching Hematology: Blood Grouping and Crossmatching Medium MEDICAL Confidence: medium