How does the Lutheran blood group system impact red blood cell membrane structure?

A It affects the expression of band 3 protein
B It alters the function of the anion exchange protein
C It modifies the interaction between red blood cell membrane and the underlying cytoskeleton ✓
D It has no significant effect on red blood cell membrane structure

Explanation

The Lutheran blood group system involves antigens that are part of the basal cell adhesion molecule (BCAM), which interacts with the cytoskeleton underneath the red blood cell membrane, thus affecting its structure.

Source

Biochemistry of Red Blood Cell Membrane Proteins
Hematology Hematology: Blood Grouping and Crossmatching Hematology: Blood Grouping and Crossmatching Hard MEDICAL Confidence: medium