How does the concentration of chloride ions affect the oxygen-binding properties of hemoglobin?

A It increases the affinity of hemoglobin for oxygen
B It decreases the affinity of hemoglobin for oxygen ✓
C It has no effect on the oxygen-binding properties of hemoglobin
D It enhances the release of oxygen from hemoglobin to the tissues

Explanation

An increase in chloride ions can decrease the affinity of hemoglobin for oxygen, facilitating the release of oxygen to the tissues.

Source

Berne and Levy Physiology
Hematology Hematology: Hemoglobin and Oxygen Transport Hematology: Hemoglobin and Oxygen Transport Medium MEDICAL Confidence: medium