How does the concentration of 2,3-bisphosphoglycerate (2,3-BPG) affect the oxygen-binding affinity of hemoglobin?

A It increases the oxygen-binding affinity of hemoglobin
B It decreases the oxygen-binding affinity of hemoglobin ✓
C It has no effect on the oxygen-binding affinity of hemoglobin
D It increases the cooperativity of oxygen binding to hemoglobin

Explanation

2,3-Bisphosphoglycerate (2,3-BPG) decreases the oxygen-binding affinity of hemoglobin, allowing for more efficient release of oxygen to tissues.

Source

Physiology textbooks
Hematology Hematology: Hemoglobin and Oxygen Transport Hematology: Hemoglobin and Oxygen Transport Easy MEDICAL Confidence: high