How does the Bohr effect influence oxygen binding to hemoglobin?

A Increased pH and decreased CO2 increase oxygen binding affinity
B Decreased pH and increased CO2 decrease oxygen binding affinity ✓
C Increased temperature increases oxygen binding affinity
D Increased 2,3-Bisphosphoglycerate increases oxygen binding affinity

Explanation

The Bohr effect describes how decreased pH (increased acidity) and increased CO2 levels decrease the oxygen binding affinity of hemoglobin, facilitating oxygen release to tissues.

Source

Berne and Levy Physiology
Hematology Hematology: Hemoglobin and Oxygen Transport Hematology: Hemoglobin and Oxygen Transport Medium MEDICAL Confidence: high