How does fetal hemoglobin (HbF) adapt to the low oxygen environment in the womb?

A By increasing its oxygen affinity through the binding of 2,3-Bisphosphoglycerate
B By decreasing its oxygen affinity through the binding of carbon monoxide
C By increasing its oxygen affinity due to the presence of gamma-subunits ✓
D By decreasing its oxygen affinity due to the presence of beta-subunits

Explanation

Fetal hemoglobin (HbF) has a higher oxygen affinity than adult hemoglobin due to the presence of gamma-subunits, which allows it to extract oxygen from the mother's bloodstream and deliver it to the fetus.

Source

Berne and Levy Physiology
Hematology Hematology: Hemoglobin and Oxygen Transport Hematology: Hemoglobin and Oxygen Transport Hard MEDICAL Confidence: high