A patient with thrombotic thrombocytopenic purpura (TTP) is treated with plasma exchange. What is the primary goal of this treatment?

A To remove autoantibodies against ADAMTS13
B To replace deficient ADAMTS13 enzyme ✓
C To remove circulating immune complexes
D To suppress platelet activation

Explanation

Plasma exchange in TTP aims to replace the deficient ADAMTS13 enzyme, which is responsible for cleaving von Willebrand factor, thereby reducing the risk of thrombosis.

Source

NEJM, 2018
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Medium MEDICAL Confidence: high