A patient with metabolic acidosis has a high anion gap. Which of the following is the most likely cause of this condition?

A Diarrhea
B Lactic acidosis ✓
C Renal failure
D Respiratory alkalosis

Explanation

A high anion gap metabolic acidosis is characterized by an increase in the difference between the measured cations (sodium) and anions (chloride and bicarbonate) in the blood. Lactic acidosis is a common cause of high anion gap metabolic acidosis, as it results in the accumulation of lactic acid, which is an unmeasured anion.

Source

Harrison's Principles of Internal Medicine
Electrolytes and Acid-Base Balance Pathophysiology Acid-Base Disorders Hard MEDICAL Confidence: high