A patient with hemophilia A is treated with recombinant factor VIII. What is the primary mechanism by which the patient's body may develop resistance to this treatment?

A Formation of inhibitory antibodies against factor VIII ✓
B Development of Factor VIII deficiency
C Increased clearance of factor VIII from the circulation
D Decreased production of von Willebrand factor

Explanation

The primary mechanism by which the body may develop resistance to recombinant factor VIII treatment in hemophilia A is through the formation of inhibitory antibodies against factor VIII, which can neutralize its activity.

Source

Clinical hematology literature
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Hard MEDICAL Confidence: high