A patient with a history of recurrent venous thromboembolism is found to have a mutation in the gene encoding for thrombomodulin. What is the likely diagnosis?

A Protein S deficiency
B Protein C deficiency
C Antithrombin deficiency
D Thrombomodulin deficiency
Thrombomodulin is a protein that binds to thrombin and activates protein C, which then inhibits coagulation. A mutation in the gene encoding for thrombomodulin can lead to a deficiency of this protein, increasing the risk of venous thromboembolism.
New England Journal of Medicine
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Hard MEDICAL Confidence: medium