A patient with a history of recurrent spontaneous abortions and thrombocytopenia is diagnosed with Antiphospholipid Syndrome. What is the underlying mechanism of this condition?

A Autoantibodies against platelet glycoproteins
B Deficiency of Protein S
C Autoantibodies against phospholipid-binding proteins ✓
D Genetic mutation in the Factor V gene

Explanation

Antiphospholipid Syndrome is an autoimmune disorder characterized by the presence of autoantibodies against phospholipid-binding proteins, which leads to thrombosis and recurrent fetal loss.

Source

Harrison's Principles of Internal Medicine
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Hard MEDICAL Confidence: high