A patient with a history of recurrent arterial thrombosis is found to have elevated levels of homocysteine. What is the most likely underlying condition?

A Homocystinuria ✓
B Factor V Leiden mutation
C Prothrombin gene mutation
D Antiphospholipid syndrome

Explanation

Elevated levels of homocysteine are associated with an increased risk of arterial thrombosis, and homocystinuria is a genetic disorder characterized by elevated levels of homocysteine due to a deficiency in cystathionine beta-synthase.

Source

Harrison's Principles of Internal Medicine
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Hard MEDICAL Confidence: high