A patient with a history of deep vein thrombosis is found to have a mutation in the gene encoding protein C. What is the most likely diagnosis?

A Protein S deficiency
B Factor V Leiden mutation
C Protein C deficiency ✓
D Antithrombin deficiency

Explanation

Protein C is an anticoagulant protein that inhibits factors Va and VIIIa. A deficiency in protein C can lead to an increased risk of thrombosis.

Source

Harrison's Principles of Internal Medicine
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Hard MEDICAL Confidence: high