A patient with a history of bleeding disorders is found to have a deficiency of plasminogen activator inhibitor-1 (PAI-1). What would be the expected outcome?

A Increased risk of thrombosis
B Decreased risk of thrombosis
C Increased risk of bleeding ✓
D Decreased risk of bleeding

Explanation

PAI-1 inhibits plasminogen activators, which are involved in fibrinolysis. A deficiency of PAI-1 would lead to increased fibrinolysis and an increased risk of bleeding.

Source

Hematology: Clinical Principles and Applications
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Hard MEDICAL Confidence: high