A patient with a deficiency of the enzyme dihydropteroate synthetase would be at risk for developing which type of metabolic disorder?

A Homocystinuria ✓
B Methemoglobinemia
C Pernicious anemia
D Hyperphenylalaninemia

Explanation

Dihydropteroate synthetase is an enzyme involved in the synthesis of tetrahydrofolate, a cofactor necessary for the conversion of homocysteine to methionine. A deficiency in this enzyme would lead to elevated levels of homocysteine, resulting in homocystinuria.

Source

Scriver's The Metabolic and Molecular Bases of Inherited Disease
Metabolic and Nutritional Disorders Genetics and Metabolism Folate Metabolism Hard MEDICAL Confidence: medium