How does the lectin pathway of complement activation relate to the ABO blood group system, particularly in terms of naturally occurring antibodies?

A Lectin pathway activation is directly triggered by ABO blood group antigens
B Naturally occurring anti-ABO antibodies are primarily activated through the lectin pathway ✓
C The lectin pathway plays no role in the activation of naturally occurring anti-ABO antibodies
D The lectin pathway is involved in the regulation of anti-ABO antibody production

Explanation

Naturally occurring anti-ABO antibodies are primarily IgM and can activate the complement system through the classical pathway, but there is evidence that the lectin pathway may also play a role in their activation.

Source

Immunohematology research articles
Hematology Hematology: Blood Grouping and Crossmatching Hematology: Blood Grouping and Crossmatching Hard MEDICAL Confidence: medium