What is the role of the immune system's complement cascade in hemolysis during ABO blood group incompatibility?

A Activation of the complement cascade leads to direct lysis of red blood cells ✓
B Inhibition of the complement cascade prevents hemolysis
C Complement cascade is not involved in ABO incompatibility hemolysis
D The complement cascade enhances the phagocytosis of red blood cells

Explanation

The immune system's complement cascade plays a crucial role in hemolysis during ABO blood group incompatibility by activating a series of proteins that lead to the direct lysis of red blood cells.

Source

Immunohematology textbooks
Hematology Hematology: Blood Grouping and Crossmatching Hematology: Blood Grouping and Crossmatching Hard MEDICAL Confidence: high