Which of the following laboratory tests is used to detect the presence of complement on the surface of red blood cells, indicating an immune-mediated hemolytic anemia?

A Direct Coombs test ✓
B Indirect Coombs test
C Osmotic fragility test
D Reticulocyte count

Explanation

The direct Coombs test, also known as the direct antiglobulin test, detects the presence of complement and/or antibodies on the surface of red blood cells, indicating an immune-mediated hemolytic anemia.

Source

Williams Hematology
Hematology Hematology: Blood Grouping and Crossmatching Hematology: Blood Grouping and Crossmatching Hard MEDICAL Confidence: high