What is the significance of the Duffy blood group system in transfusion medicine, particularly in relation to Plasmodium vivax infection?

A It provides protection against malaria ✓
B It increases the risk of hemolysis
C It is associated with increased expression of Rh antigens
D It has no clinical significance in transfusion medicine

Explanation

The Duffy blood group system is significant in transfusion medicine because the Duffy antigen acts as a receptor for Plasmodium vivax, making individuals lacking this antigen (such as those with the Duffy negative phenotype) resistant to P. vivax infection.

Source

Transfusion Medicine textbooks
Hematology Hematology: Blood Grouping and Crossmatching Hematology: Blood Grouping and Crossmatching Hard MEDICAL Confidence: high