How does the phenomenon of 'chimerism' impact blood typing and crossmatching in recipients of bone marrow transplants?

A It leads to the production of antibodies against the donor's blood cells
B It results in the recipient's blood type changing to match the donor's
C It has no significant impact on blood typing and crossmatching
D It can lead to mixed chimerism, where both donor and recipient cells coexist, complicating blood typing ✓

Explanation

Chimerism, especially mixed chimerism, can complicate blood typing and crossmatching because both donor and recipient red blood cells may be present, potentially leading to unexpected reactions during crossmatching.

Source

Transfusion Medicine texts
Hematology Hematology: Blood Grouping and Crossmatching Hematology: Blood Grouping and Crossmatching Hard MEDICAL Confidence: high