Which of the following blood group antigens is most likely to cause an acute hemolytic transfusion reaction due to its high immunogenicity?

A K1 antigen
B D antigen
C C antigen
D E antigen
The D antigen is highly immunogenic and can cause an acute hemolytic transfusion reaction if an individual with anti-D antibodies receives D-positive blood.
Transfusion Medicine textbook
Hematology Hematology: Blood Grouping and Crossmatching Hematology: Blood Grouping and Crossmatching Hard MEDICAL Confidence: high