What is the significance of the Duffy blood group system in transfusion medicine, particularly in relation to malaria?

A It is associated with a higher risk of hemolytic disease of the newborn
B It provides protection against malaria, especially in individuals with the Fy(a-b-) phenotype ✓
C It is responsible for the production of antibodies against the K1 antigen
D It is used as a marker for blood typing in patients with sickle cell disease

Explanation

The Duffy blood group system has been implicated in the protection against malaria, particularly in individuals with the Fy(a-b-) phenotype, which is more common in populations from areas with high malaria endemicity.

Source

Transfusion Medicine textbooks
Hematology Hematology: Blood Grouping and Crossmatching Hematology: Blood Grouping and Crossmatching Hard MEDICAL Confidence: high