What is the purpose of using a two-stage crossmatch in blood banking?

A To detect ABO incompatibility
B To identify individuals with a rare blood type
C To reduce the risk of transfusion-related acute lung injury (TRALI)
D To enhance the sensitivity of antibody detection and prevent hemolytic reactions ✓

Explanation

A two-stage crossmatch involves an initial screening for antibodies using an indirect antiglobulin test, followed by a direct antiglobulin test to detect any bound antibodies, enhancing the sensitivity of antibody detection and reducing the risk of hemolytic reactions.

Source

AABB Technical Manual
Hematology Hematology: Blood Grouping and Crossmatching Hematology: Blood Grouping and Crossmatching Medium MEDICAL Confidence: high