How does the cold agglutinin disease (CAD) impact blood transfusion practices, particularly in terms of pre-transfusion testing?

A It requires additional testing for cold agglutinins ✓
B It necessitates the use of warmed blood products
C It involves the use of specific antigen-negative blood products
D It does not affect blood transfusion practices

Explanation

Cold agglutinin disease (CAD) is a condition where the body produces antibodies that attack red blood cells at cold temperatures. This condition requires additional testing for cold agglutinins before blood transfusion to prevent hemolysis.

Source

Transfusion Medicine Guidelines
Hematology Hematology: Blood Grouping and Crossmatching Hematology: Blood Grouping and Crossmatching Medium MEDICAL Confidence: high