What is the clinical significance of hemolysis due to cold agglutinin disease in patients with certain types of infections?

A It can lead to severe anemia and jaundice ✓
B It can cause thrombocytopenia and leukopenia
C It can result in disseminated intravascular coagulation
D It has no significant clinical impact

Explanation

Cold agglutinin disease is a condition where the immune system produces antibodies that attack red blood cells at cold temperatures, leading to hemolysis. In patients with certain types of infections, such as Mycoplasma pneumoniae or Epstein-Barr virus, this can result in severe anemia and jaundice.

Source

Clinical hematology textbooks
Hematology Hematology: Blood Grouping and Crossmatching Hematology: Blood Grouping and Crossmatching Medium MEDICAL Confidence: medium