Which of the following blood group antigens is responsible for the majority of acute hemolytic transfusion reactions due to its high immunogenicity?

A RhD antigen
B Kell antigen
C Duffy antigen
D ABO antigen ✓

Explanation

The ABO antigen is highly immunogenic and is responsible for the majority of acute hemolytic transfusion reactions.

Source

AABB Technical Manual
Hematology Hematology: Blood Grouping and Crossmatching Hematology: Blood Grouping and Crossmatching Hard MEDICAL Confidence: high