A patient with a diagnosis of thrombotic thrombocytopenic purpura (TTP) is most likely to have a deficiency in which of the following enzymes?

A ADAMTS13 ✓
B Factor XIII
C Protein C
D Plasminogen activator

Explanation

Thrombotic thrombocytopenic purpura (TTP) is a rare blood disorder characterized by a deficiency in ADAMTS13, a metalloprotease enzyme responsible for cleaving von Willebrand factor.

Source

New England Journal of Medicine
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Hard MEDICAL Confidence: high