A patient is diagnosed with a rare coagulation disorder known as Sticky Platelet Syndrome, characterized by an abnormality in platelet function leading to a hypercoagulable state. What is the most likely underlying defect in this condition?

A Abnormal platelet adhesion due to von Willebrand factor deficiency
B Enhanced platelet aggregation due to abnormal platelet membrane glycoproteins ✓
C Impaired platelet secretion leading to reduced anti-thrombotic substances release
D Deficiency in platelet cyclooxygenase leading to reduced thromboxane A2 production

Explanation

Sticky Platelet Syndrome is characterized by an increased tendency for platelets to aggregate, often due to abnormalities in the platelet membrane glycoproteins that facilitate this aggregation, leading to a hypercoagulable state.

Source

Specialized hematology literature and case reports
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Hard MEDICAL Confidence: medium