Which coagulation disorder is characterized by an autosomal dominant inheritance pattern and is caused by a mutation in the PROS1 gene?

A Protein C deficiency
B Protein S deficiency ✓
C Factor V Leiden thrombophilia
D Antithrombin deficiency

Explanation

Protein S deficiency is an autosomal dominant disorder caused by mutations in the PROS1 gene, leading to an increased risk of venous thromboembolism.

Source

New England Journal of Medicine
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Hard MEDICAL Confidence: medium