What is the primary mechanism by which desmopressin increases factor VIII and von Willebrand factor levels in patients with mild hemophilia A and von Willebrand disease?

A Increased synthesis of factor VIII and von Willebrand factor
B Release of factor VIII and von Willebrand factor from storage sites ✓
C Inhibition of factor VIII and von Willebrand factor degradation
D Enhanced binding of factor VIII to von Willebrand factor

Explanation

Desmopressin increases factor VIII and von Willebrand factor levels by releasing them from storage sites, such as endothelial cells.

Source

Williams Hematology, 9th edition
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Medium MEDICAL Confidence: high