Which of the following coagulation factors is synthesized by the liver and is vitamin K-dependent?

A Factor V
B Factor VIII
C Factor IX
D All of the above except Factor VIII ✓

Explanation

Factors II, VII, IX, and X are vitamin K-dependent coagulation factors synthesized by the liver. Factor V is also synthesized by the liver but is not vitamin K-dependent. Factor VIII is synthesized by endothelial cells and is not vitamin K-dependent.

Source

Guyton and Hall Textbook of Medical Physiology
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Medium MEDICAL Confidence: high