What is the role of thrombomodulin in the coagulation cascade?
A
It activates protein C, which then inhibits factors Va and VIIIa
✓
B
It inhibits the activation of factor X by factor VIIa
C
It enhances the binding of von Willebrand factor to platelets
D
It stimulates the production of tissue factor
Explanation
Thrombomodulin is a thrombin receptor on endothelial cells that binds to thrombin and changes its activity from a procoagulant to an anticoagulant, activating protein C.
Source
Guyton and Hall Textbook of Medical Physiology
Hematology
Hematology: Coagulation Disorders
Hematology: Coagulation Disorders
Medium
MEDICAL
Confidence: high
