A patient presents with a history of recurrent venous thrombosis and is found to have a mutation in the factor V gene. What is the most likely diagnosis?

A Protein C deficiency
B Protein S deficiency
C Antithrombin III deficiency
D Factor V Leiden mutation
The factor V Leiden mutation is a common cause of inherited thrombophilia, leading to an increased risk of recurrent venous thrombosis. This mutation results in the production of a variant of factor V that is resistant to inactivation by activated protein C.
Harrison's Principles of Internal Medicine
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Hard MEDICAL Confidence: high