What is the mechanism by which activated protein C inactivates coagulation factors Va and VIIIa in the coagulation cascade?

A By binding to phospholipid surfaces
B By cleaving the factors at specific sites ✓
C By recruiting protein S as a cofactor
D By inhibiting the production of thrombin

Explanation

Activated protein C (APC) is a crucial anticoagulant that functions by proteolytically inactivating coagulation factors Va and VIIIa, thus downregulating the coagulation pathway. This action requires a cofactor, protein S, and takes place on phospholipid surfaces, but the direct mechanism involves cleavage at specific sites.

Source

Hematology textbooks and research articles
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Hard MEDICAL Confidence: high