What is the mechanism of action of recombinant factor VIIa in treating bleeding episodes in patients with hemophilia with inhibitors?

A It binds to and inhibits the activity of factor VIII inhibitors
B It bypasses the inhibitor and promotes hemostasis by activating factor X ✓
C It induces the production of factor VIII by binding to the promoter region of the F8 gene
D It inhibits the activity of tissue factor pathway inhibitor

Explanation

Recombinant factor VIIa works by bypassing the inhibitor and promoting hemostasis by activating factor X, which then activates prothrombin to thrombin, leading to fibrin formation and clot stabilization.

Source

New England Journal of Medicine
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Hard MEDICAL Confidence: high