A patient with a history of recurrent venous thromboembolism is found to have a mutation in the gene encoding protein C. What is the most likely diagnosis?

A Protein C deficiency ✓
B Protein S deficiency
C Antithrombin deficiency
D Factor V Leiden mutation

Explanation

A mutation in the protein C gene can lead to a deficiency of protein C, a vitamin K-dependent anticoagulant protein that regulates the coagulation cascade.

Source

Harrison's Principles of Internal Medicine
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Hard MEDICAL Confidence: high