What is the primary cause of thrombocytopenia in patients with heparin-induced thrombocytopenia?

A Autoantibodies against platelet factor 4 ✓
B Immune complex-mediated destruction of platelets
C Direct toxicity of heparin on platelets
D Activation of the complement system

Explanation

Heparin-induced thrombocytopenia is caused by autoantibodies against platelet factor 4, which bind to heparin and activate platelets, leading to their destruction.

Source

Williams Hematology, 9th edition
Hematology Hematology: Coagulation Disorders Hematology: Coagulation Disorders Hard MEDICAL Confidence: high